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Cushing's disease occurs due to an excess of which substance?

  1. Insulin

  2. Cortisone

  3. Adrenaline

  4. Thyroxine

The correct answer is: Cortisone

Cushing's disease is characterized by an overproduction of cortisol, which is a hormone produced by the adrenal glands. The specific substance that causes Cushing's disease is often cortisone, as it is closely related to cortisol and can also exhibit similar effects in the body. The condition typically stems from pituitary gland issues that lead to excessive adrenocorticotropic hormone (ACTH) production, which stimulates the adrenal glands to produce more cortisol and subsequently cortisone. The other choices are either hormones that play different roles or are produced in different glands. Insulin primarily regulates glucose levels and is produced by the pancreas. Adrenaline, on the other hand, is involved in the body's fight-or-flight response and is produced by the adrenal medulla. Thyroxine is a hormone produced by the thyroid gland that regulates metabolism. Therefore, cortisone is the substance whose excess primarily results in the symptoms and complications associated with Cushing's disease.